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This is a monthly feature that runs down some of the most-active investors in U.S.-based companies, looks at some of their most interesting investments, and includes some odds and ends of who spent what. See August鈥檚 most-active startup investors here.

October turned out to be a pretty busy month for many of the big names in venture and was led again by .

Other investors such as and followed closely,聽 all investing in 11 or more rounds involving U.S.-based companies.

Interestingly, none of those firms took part in the big round of the month 鈥� 鈥檚 massive $6.6 billion raise 鈥� but they all clearly found a lot of other deals to their liking.

Andreessen Horowitz, 14 deals

Few firms have been as busy as Andreessen Horowitz. In the three months before October, the Menlo Park, California-based giant made 32 deals involving U.S.-based startups.

A16z had its busiest month of the year in October, taking part in 14 rounds with U.S. startups. The biggest was in New York-based mortgage servicing platform 鈥� $100 million Series C led by .

The largest round the company led was a $51.5 million Series C for San Francisco-based , which has developed an AI platform specifically built to automate manual healthcare phone calls.

General Catalyst, 12 deals

General Catalyst also had one of its biggest months with a dozen deals announced, which tied with April.

While that鈥檚 impressive, what is perhaps most notable is the two huge rounds it led 鈥� or co-led 鈥� in a three-day span.

On Oct. 25, it led a $900 million Series A for , a startup attempting to create a nuclear fusion-based energy source. It quickly followed that on Oct. 28 by co-leading cybersecurity startup 鈥檚 big $200 million Series D along with .

Lightspeed Venture Partners, 11 deals

Continuing our theme, Lightspeed also invested in more rounds involving U.S.-based startups last month than in any other month so far this year. That included taking part in the big Pacific Fusion round.

It also took part in the $135 million Series D for San Francisco-based , a legal tech startup creating artificial intelligence products for the personal injury sector.

The largest domestic round it co-led was payment processing startup 鈥檚 $75M Series C along with and .

Sequoia Capital and Alumni Ventures, 9 deals each

Unlike the other firms on this list so far, neither nor set year-high marks for investments last month.

However, that鈥檚 not to say they didn’t take part in some notable rounds.

Alumni participated in 鈥檚 $150 million Series B. The Redondo Beach, California-based space startup is developing a line of orbital transfer vehicles 鈥� also called 鈥渟pace tugs鈥� 鈥� which serve as a last-mile cargo delivery service once payloads get into orbit.

Sequoia helped New York-based teletherapy startup lock up a $125 million Series F that values the startup at $1.7 billion. Maven partners with employers and health plans to provide clinical support concerning preconception, family building, pregnancy, parenting and menopause.

Also notable:

• came in next on the list with eight deals.
• Lightspeed Venture Partners and General Catalyst led the way in most led or co-led deals in October with six each.
• led the list for number of rounds led or co-led with the highest dollar amounts with two at more than $6.6 billion 鈥� including OpenAI鈥檚 long-awaited raise of $6.6 billion at a post-money valuation of $157 billion.
• once again was the top investing incubator and accelerator with 18 deals in October.

Related reading:

• AI, Data Center And Energy Startups Get Large Capital Infusion In October
• OpenAI Raises $6.6B At $157B Valuation
• Cyber Startup Armis Security Raises $200M At $4.2B Valuation
• AI Legal Tech Startup EvenUp Raises $135M To Hit Unicorn Status

Methodology

This is a list of investors which took part in the most rounds involving U.S.-based startups. It does not include incubators or accelerators due to the fluctuations their investment numbers can have.

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